GLP-1 Dose & Titration Calculator
Preset semaglutide and tirzepatide vials with a full week-by-week titration schedule. Choose your vial, add your bacteriostatic water, and see the exact units to draw on a to-scale insulin syringe for every step.
Loading the GLP-1 calculator
Pick a GLP-1, choose a preset vial, add your bacteriostatic water, and read the exact units to draw for each step of your titration.
How to calculate your GLP-1 dose
- 1Pick your GLP-1 and vial. Choose semaglutide or tirzepatide, then select the preset vial strength printed on your label.
- 2Add your bacteriostatic water. Enter how much bacteriostatic water you mixed in to set the concentration in mg/mL.
- 3Choose your syringe. Select the insulin syringe you inject with so the draw is rendered to scale with over-draw warnings.
- 4Read your titration schedule. See the exact units to draw for each week of the standard titration ladder, from starting dose to maintenance.
Standard titration ladders
Semaglutide
Ozempic, Wegovy
0.25 mg → 0.5 mg → 1 mg → 1.7 mg → 2.4 mg weekly, escalating every 4 weeks.
Tirzepatide
Mounjaro, Zepbound
2.5 mg → 5 mg → 7.5 mg → 10 mg → 12.5 mg → 15 mg weekly, escalating every 4 weeks.
Retatrutide
Triple G, GGG
1 mg → 2 mg → 4 mg → 6 mg → 8 mg → 12 mg weekly, escalating every 4 weeks.
Common questions
- How many units of semaglutide is 0.25 mg?
- It depends on how you reconstitute the vial. With a 5 mg vial in 2 mL of bacteriostatic water (2.5 mg/mL), 0.25 mg is 0.1 mL, which is 10 units on a U-100 insulin syringe. Change the vial size or water volume and the calculator recomputes the units for you.
- What is a standard semaglutide titration schedule?
- A common protocol starts at 0.25 mg weekly for four weeks, then steps up to 0.5 mg, 1 mg, 1.7 mg, and a 2.4 mg maintenance dose, escalating every four weeks to limit gastrointestinal side effects. This calculator lays out each step with the exact units to draw.
- What is a standard tirzepatide titration schedule?
- Tirzepatide typically starts at 2.5 mg weekly for four weeks, then increases through 5, 7.5, 10, 12.5, and up to 15 mg, stepping up every four weeks as tolerated. The schedule shows the draw for each step based on your reconstitution.
- How much bacteriostatic water should I add to a GLP-1 vial?
- Most people add 1-3 mL. Adding 2 mL to a 5 mg semaglutide vial gives 2.5 mg/mL, a clean ratio where 0.25 mg is 10 units. Less water makes a more concentrated solution and a smaller draw; more water makes the draw larger and easier to read.
- Is this the same as an Ozempic, Wegovy, Mounjaro or Zepbound pen?
- Semaglutide is the active ingredient in Ozempic and Wegovy; tirzepatide is the active ingredient in Mounjaro and Zepbound. Branded products are pre-filled dial-a-dose pens. This tool is for reconstituting compounded vials and drawing the dose with an insulin syringe.
- Which syringe is best for GLP-1 dosing?
- A 0.3 mL (30-unit) syringe gives the most precise measurement for small semaglutide draws, while higher tirzepatide doses often need a 0.5 mL or 1 mL syringe. The calculator warns you whenever a dose exceeds the capacity of the syringe you pick.
Working with a different compound or a custom dose? Use the Dose & Reconstitution Calculator.
For educational and research purposes only. Not medical advice. Always consult a licensed healthcare professional.
Related reading
- Dosing fundamentals
Reading an Insulin Syringe: Units vs mL
On a standard U-100 insulin syringe, 100 units equal 1 mL, so each unit is 0.01 mL. To convert a dose volume to units, multiply the millilitres by 100. Insulin syringes come in 0.3 mL (30 units), 0.5 mL (50 units), and 1 mL (100 units) sizes; smaller barrels give finer, more accurate marks for small draws.
- GLP-1 therapy
GLP-1 Titration Basics
GLP-1 titration means starting at a low weekly dose and stepping up in fixed increments every few weeks. Community and anecdotal reports commonly describe semaglutide moving from about 0.25 mg toward 2.4 mg and tirzepatide from about 2.5 mg toward 15 mg. These are figures people report, not recommendations. Gradual escalation is described as giving the gut time to adapt.
- GLP-1 therapy
GLP-1 Microdosing Explained
GLP-1 microdosing means using semaglutide, tirzepatide, or retatrutide at doses well below standard therapeutic targets, aiming for a gentler effect with fewer side effects. Protocols use either a slow low-dose ladder or an extended hold at a single small dose. Reconstituting with more water makes these tiny draws easier to measure.