GLP-1 Titration Basics
GLP-1 titration means starting at a low weekly dose and stepping up in fixed increments every few weeks. Community and anecdotal reports commonly describe semaglutide moving from about 0.25 mg toward 2.4 mg and tirzepatide from about 2.5 mg toward 15 mg. These are figures people report, not recommendations. Gradual escalation is described as giving the gut time to adapt.
For educational and research purposes only. Not medical advice. Always consult a licensed healthcare professional before starting any protocol.
Why titrate at all
GLP-1 receptor agonists slow gastric emptying and act on appetite signalling, and the most common side effects, nausea, are dose-related and tend to ease as the body adapts. Starting at a full maintenance dose would overwhelm most people, so protocols begin low and increase gradually. This gradual increase is called titration.
The starting dose is usually below the therapeutic target; it exists to build tolerance, not to deliver the full effect. Each step up holds for a set number of weeks before the next increase.
Commonly reported ladders
Community and anecdotal reports commonly describe semaglutide ladders that start around 0.25 mg once weekly for four weeks, then step through 0.5 mg, 1 mg, 1.7 mg, and up to a 2.4 mg maintenance dose, moving up roughly every four weeks. Tirzepatide ladders are reported starting around 2.5 mg weekly for four weeks, then stepping through 5, 7.5, 10, 12.5, and up to 15 mg.
These are patterns people report, not prescriptions or recommendations from Keel. Many people report holding longer at a step if side effects are strong, or stopping once they reach a dose that works for them. The recurring theme is small, spaced increments rather than large jumps.
Calculating each step
Because each rung of the ladder is a different milligram dose, the units you draw change at every step. Reconstitute the vial once to fix the concentration, then recalculate the draw for each new dose. The GLP-1 calculator lays out the full ladder with the exact units per step, and the titration schedule builder lets you set custom starting doses, increments, and hold lengths for any compound.
Frequently asked questions
What semaglutide titration schedule do people report?
A commonly reported schedule is around 0.25 mg weekly for four weeks, then 0.5 mg, 1 mg, 1.7 mg, and a 2.4 mg maintenance dose, escalating about every four weeks. These are figures people report, not medical advice; recalculate the units to draw at each step.
What tirzepatide titration schedule do people report?
Community and anecdotal reports commonly describe tirzepatide starting around 2.5 mg weekly for four weeks, then stepping through 5, 7.5, 10, 12.5, and up to 15 mg, roughly every four weeks. These are reported figures, not recommendations.
How fast should I increase my dose?
Most ladders hold each step for about four weeks, but the right pace depends on how you tolerate each dose. Slower is fine; the goal is to limit side effects, not to reach the top of the ladder quickly.
Do the units I draw change as I titrate?
Yes. Each step is a different milligram dose, so the volume and units change even though the concentration stays the same. Recalculate the draw at every step.
Related tools
GLP-1 Dose & Titration Calculator
Free dose calculator for semaglutide and tirzepatide. Get a week-by-week titration schedule with the exact units to draw on a to-scale insulin syringe.
Titration Schedule Builder
Titration schedule builder for any peptide or GLP-1: enter starting dose, target, increment, and step length to get a dated week-by-week plan with the exact units to draw.