Retatrutide Dosing Calculator & Reconstitution Guide
An investigational triple agonist (GIP/GLP-1/glucagon) studied for weight loss.
Retatrutide is a GLP-1 receptor agonist. An investigational triple agonist (GIP/GLP-1/glucagon) studied for weight loss. To dose it, reconstitute the vial (for example 10 mg in 2 mL of bacteriostatic water for 5 mg/mL), then divide your target dose by that concentration to find the units to draw.
- Category
- GLP-1 receptor agonist
- Dose unit
- mg
- Commonly reported range
- 1-12 mg
- Typical concentration
- 5 mg/mL
Use the Keel dose calculator to enter your numbers and see the exact units to draw, or use the built-in calculator further down this page.
What is Retatrutide?
Retatrutide is an investigational triple receptor agonist targeting GIP, GLP-1, and glucagon receptors. It is dosed once weekly and titrated upward. Doses in trials have ranged up to 12 mg weekly. Also known as reta, triple G, GGG.
How many units is each Retatrutide dose?
| Dose | Volume to draw | Units (U-100) |
|---|---|---|
| 1 mg | 0.2 mL | 20 units |
| 2 mg | 0.4 mL | 40 units |
| 4 mg | 0.8 mL | 80 units |
| 8 mg | 1.6 mL | 160 units |
| 12 mg | 2.4 mL | 240 units |
Based on a 10 mg vial reconstituted with 2 mL of bacteriostatic water (5 mg/mL) and a U-100 insulin syringe. The dose amounts shown are commonly reported by the community and in anecdotal research, not recommendations or medical advice; only the reconstitution math (volume and units) is calculated for you.
How to calculate a Retatrutide dose
- 1
Choose your vial and water
Select your Retatrutide vial size (for example 10 mg) and the volume of bacteriostatic water you will add (for example 2 mL).
- 2
Find the concentration
Divide vial milligrams by water volume. 10 mg in 2 mL gives 5 mg/mL.
- 3
Calculate the draw
Divide your target dose by the concentration to get the volume in mL, then multiply by 100 to get units on a U-100 insulin syringe.
- 4
Verify on the syringe
Use the Keel calculator to see the exact draw rendered on a to-scale syringe, with a warning if the dose exceeds the syringe capacity.
Retatrutide dosing FAQ
How do I reconstitute Retatrutide?
A common approach is to add 2 mL of bacteriostatic water to a 10 mg vial, which gives 5 mg/mL. Add the water slowly down the vial wall, swirl gently rather than shaking, and let the powder dissolve fully before drawing.
How many units is 2 mg of Retatrutide?
At 5 mg/mL, 2 mg equals 0.4 mL, which is 40 units on a U-100 insulin syringe.
What Retatrutide doses do people report?
Community and anecdotal reports commonly cite 1 to 12 mg. These are figures people report, not a recommendation from Keel. Retatrutide is an investigational triple receptor agonist targeting GIP, GLP-1, and glucagon receptors. It is dosed once weekly and titrated upward. Doses in trials have ranged up to 12 mg weekly.
Which insulin syringe should I use for Retatrutide?
A U-100 insulin syringe is standard. A 0.3 mL (30-unit) syringe gives the most precise measurement for small draws, while a 0.5 mL or 1 mL syringe is better when the draw exceeds 30 units. Keel warns you when a dose is larger than the syringe you select.
How should I store Retatrutide after reconstitution?
Reconstituted peptides are generally kept refrigerated and protected from light, with the unmixed powder stored cooler still. Follow the guidance from your supplier or a licensed healthcare professional for the specific compound.
What if my Retatrutide dose is larger than the syringe holds?
Either use a larger insulin syringe or reconstitute with more bacteriostatic water to lower the concentration, which increases the volume per dose so it fits. Keel flags an over-draw and you can adjust the inputs until the draw fits.
Is Retatrutide dosing the same for everyone?
No. The right draw depends on your vial size, how much bacteriostatic water you add, and your target dose. Always recalculate when any of those change, and consult a licensed healthcare professional.
Retatrutide side effects
See the adverse effects most commonly reported for Retatrutide and its class, and log your own experience over time, in the Peptide & GLP-1 Side Effects reference & tracker.